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Familial parkinsonism with depression: A clinicopathological study
Author(s) -
Bhatia K. P.,
Daniel S. E.,
Marsden C. D.
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340614
Subject(s) - parkinsonism , depression (economics) , pathological , substantia nigra , medicine , gliosis , psychology , pathology , psychiatry , parkinson's disease , disease , economics , macroeconomics
A family with autosomal dominant inheritance of an early‐onset and rapidly progressive parkinsonian syndrome and associated severe depression is reported. Three members had parkinsonism with depression, 3 had parkinsonism alone, and 2 suffered depression only. Pathological brain examination in 2 members with parkinsonism and depression revealed distinctive changes, with devastation of the substantia nigra, scarce Lewy bodies, and gliosis of the caudate nucleaus and globus pallidus. The clinical and pathological findings were similar to those in four previously described families with autosomal dominant parkinsonism, depression, and alveolar hypoventilation.