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Cerebrospinal fluid inhibits Alzheimer β‐amyloid fibril formation in vitro
Author(s) -
Wisniewski Thomas,
Castano Eduardo,
Ghiso Jorge,
Frangione Blas
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340422
Subject(s) - cerebrospinal fluid , fibril , amyloid (mycology) , in vitro , chemistry , peptide , beta (programming language) , amyloid beta , amyloid fibril , alzheimer's disease , pathology , biophysics , biochemistry , disease , medicine , amyloid β , biology , computer science , programming language
Alzheimer's disease is characterized by the deposition of β‐protein (Aβ) as amyloid. Recently, it was found that Aβ is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to Aβ form amyloid‐like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to Aβ1–40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.
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