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Herpes simplex type 1 encephalitis in acquired immunodeficiency syndrome
Author(s) -
Tan Stella V.,
Guiloff Roberto J.,
Scaravilli Francesco,
Klapper Paul E.,
Cleator Graham M.,
Gazzard Brian G.
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340418
Subject(s) - virology , encephalitis , medicine , immunodeficiency , simplex , herpes simplex virus , immunology , virus , mathematics , immune system , geometry
A severe acute necrotizing herpes simplex virus type 1 encephalitis, apparently mediated by macrophages or cytokines or both, was seen in a patient with acquired immunodeficiency syndrome. The necrosis had a distribution similar to that seen in immunocompetent subjects. Viral inclusions were abundant and meningeal reaction was minimal, as previously described in one anergic patient.