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Failure of 3,4‐diaminopyridine to reverse conduction block in inflammatory demyelinating neuropathies
Author(s) -
Bergin Peter S.,
Miller David H.,
Hirsch Nicholas P.,
Murray Nicholas M. F.
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340318
Subject(s) - medicine , 4 aminopyridine , chronic inflammatory demyelinating polyneuropathy , guillain barre syndrome , nerve conduction , block (permutation group theory) , nerve conduction study , anesthesia , immunology , antibody , potassium channel , geometry , mathematics
3,4‐Diaminopyridine was administered to 6 patients with inflammatory demyelinating neuropathies in whom partial conduction block was demonstrable. Four had Guillain‐Barré syndrome and 2 had chronic inflammatory demyelinating neuropathy. Nerve conduction studies were performed before the administration of a single oral dose of 3,4‐diaminopyridine, and at regular intervals thereafter. Neither resolution of conduction block nor clinical benefit were seen.