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Decreased hippocampal muscarinic cholinergic receptor binding measured by 123 I‐iododexetimide and single‐photon emission computed tomography in epilepsy
Author(s) -
MüllerGärtner Hans W.,
Mayberg Helen S.,
Fisher Robert S.,
Lesser Ronald P.,
Wilson Alan A.,
Ravert Hayden T.,
Dannals Robert F.,
Wagner Henry N.,
Uematsu Sumio,
Frost J. James
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340221
Subject(s) - epilepsy , muscarinic acetylcholine receptor , hippocampal formation , single photon emission computed tomography , cholinergic , emission computed tomography , neuroscience , hippocampus , medicine , nuclear medicine , nuclear magnetic resonance , receptor , physics , psychology , positron emission tomography
Regional binding of 123 I‐iododexetimide, a muscarinic acetylchline receptor antagonist, was measured in vivo in the temporal lobes of 4 patients with complex partial seizures using single‐photon emissions computed tomography. In the anterior hippocampus ipsilateral to the electrical focus, 123 I‐iododexetimide binding was decreased by 40 ± 9% (mean 7plusmn; SD, p <0.01) compared with the contralateral hippocampus; 123 I‐iododexetimide binding in other temporal lobe regions was symmetrical. The data indicate a regionally specific change of muscarinic acetylcholine receptor in anterior hippocampus in complex partial seizures of temporal lobe origin.