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Dopa resistance in multiple‐system atrophy: Loss of postsynaptic D2 receptors
Author(s) -
Churchyard A.,
Donnan G. A.,
Hughes A.,
Howells D. W.,
Woodhouse D.,
Wong J. Y. F.,
Kalnins R. M.,
Mendelsohn F. A. O.,
Paxinos G.
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340219
Subject(s) - postsynaptic potential , atrophy , neuroscience , receptor , medicine , biology
Postmortem autoradiography was used to explor the mechanisms underlying L‐dopa resistance in 2 patients with multiple‐system atrophy. Indices of striatal presynaptic dopamine terminal loss and dopamine (D1 and D2) receptors were provided by 3 H‐SCH 23390, and 123 I‐sulpiride binding. Neuronal loss, gliosis, and loss of postsynaptic D2 receptors preferentially involved the middle and posterior of the putamen, that region of the striatum most intimately involved in motor function. Loss of D1 receptors in the same area occurred in only 1 patient. These findings suggest that in multiple‐system atrophy, resistance to L‐dopa is due to a loss of putamental D2 receptors. The differential effects on D1 and D2 receptors in 1 patient implies that different subpopulations of striatal neurons were selectively involved.