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Quantitative cerebrospinal fluid cytology in patients receiving intracavitary chemotherapy
Author(s) -
Russack Valentina,
Kim Sinil,
Chamberlain Marc C.
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410340118
Subject(s) - cytology , cerebrospinal fluid , medicine , malignancy , chemotherapy , pathology , radiology
Abstract Cytological evaluation of cerebrospinal fluid (CSF) is an important means of following response to intracavitary chemotherapy for leptomeningeal malignancy. We studied the feasibility of quantitative cytological evaluation by retrospective analysis of serial CSF specimens from 7 patients receiving phase I intracavitary chemotherapy for leptomeningeal malignancy who had persistent malignant cytology. Three to 34 CSF specimens per patient obtained over a 3‐ to 48‐week period were reviewed. Significant (five‐ to 10‐fold or greater) reductions in numbers of malignant cells in CSF during treatment could be identified in specimens otherwise diagnosed as positive. Quantitative CSF cytological evaluation is neither overly time consuming nor tedious to perform and may provide useful clinical information.