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Increases levels of circulating intercellular adhesion molecule‐1 in multiple sclerosis and human T‐lymphotropic virus type I‐associated myelopathy
Author(s) -
Tsukada N.,
Miyagi K.,
Matsuda M.,
Yanagisawa N.
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410330614
Subject(s) - multiple sclerosis , myelopathy , medicine , immunology , tumor necrosis factor alpha , intercellular adhesion molecule 1 , virus , cell adhesion molecule , spinal cord , psychiatry
We evaluated the presence of soluble intercellular adhesion molecule‐1(slCAM‐1)antigen in the sera of patients with multiple sclerosis and human T‐lymphotropic virus type I(HTLV‐I)‐associated myelopathy (HAM) using an enzyme‐linked immunosorbent assay. Patients with multiple sclerosis in the active phase had higher sICAM serum levels than did control subject ( p < 0.01). In addition, a significantly increased serum level of sICAM‐1 was found in patients with HAM ( p < 0.001). Furthermore, we found a positive correlation with HAM sICAM‐1 and tumor necrosis factor‐α levels in the sera of patients with multiple sclerosis in the active phase (=0.88, p < 0.01) and in those with HAM (r=0.86, p < 0.01). These results suggest that serum sICAM‐1 may be related to clinical activity in patients with multiple sclerosis and the detection of sICAM‐1 could be useful as a marker of inflammatory disease.