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Systemic histiocytosis presenting as multiple sclerosis
Author(s) -
Smith M. E.,
Katz D. A.,
Harris J. O.,
Frank J. A.,
Kufta C. V.,
McFarlin D. E.
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410330521
Subject(s) - multiple sclerosis , histiocytosis , medicine , dermatology , pathology , immunology , disease
A Patient resembling one with progressive multiple sclerosis in clinical presentation and by magnetic resonance imaging was studied in detail. Some features atypical for multiple sclerosis prompted a persistent search for an alternative cause. The diagnosis of a non‐Langerhans systemic histiocytosis involving brain and bone was established and showed a partial response to radiation therapy. This patient illustrates the continued importance of a broad approach to the evaluation of possible multiple sclerosis, with particular attention to atypical features.