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Campylobacter jejuni strains from patients with guillain‐barré syndrome belong mostly to penner serogrpup 19 and contain β‐ N ‐acetylglucosamine residues
Author(s) -
Kuroki Shigekazu,
Saida Takahiko,
Nukina Massafumi,
Haruta Tsunekazu,
Yoshioka Mieko,
Kobayashi Yutaka,
Nakanishi Hisao
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410330304
Subject(s) - campylobacter jejuni , guillain barre syndrome , typing , enteritis , microbiology and biotechnology , virology , medicine , serology , biology , immunology , bacteria , antibody , genetics
Campylobactor jejuni was isolacted from stool cultures from 14(30%) of 46 partients with Guillain‐Barré syndrome and from 6(1.2%) of healthy persons, and the difference was highly significant (P<0.0001). In addition, serological evidence of recent. C. Jejuni infection. Ten of 12(83%) isolated from partients with Guillain‐Barré syndrome belonged to Penner serogroup 19, which is a rare serogroup in sporadic patients with C. Jejuni enterties. In the lection typing stude, all serogroup 19 strains from patients with Guillain‐Barré syndrome patients with Guillain‐Barré syndrome were shown to contain terminal b̃‐N‐acetylglucosamine residues on their cell surface, bur serogroup 19 strains from patients with enteritis were not.