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Pathological findings at the site of conduction block in multifocal motor neuropathy
Author(s) -
Kaji Ryuji,
Oka Nobuyuki,
Tsuji Teruyuki,
Mezaki Takahiro,
Nishio Takeshi,
Akiguchi Ichiro,
Kimura Jun
Publication year - 1993
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410330204
Subject(s) - pathological , multifocal motor neuropathy , motor nerve , medicine , nerve conduction , sensory nerve , pathology , sensory system , anatomy , neuroscience , psychology , mismatch negativity , surgery , electroencephalography , psychiatry
We report on 2 patients with multifocal motor neuropathy with focal conduction block involving motor but not sensory fibers at the site of nerve swelling. A nerve biopsy specimen from adjacent to the enlargement in 1 patient showed a perivascular area containing scattered demyelinated axons surrounded by small onion bulbs. The observed pathological findings are consistent with the conduction block considered characteristic of this neuropathy, although the underlying immunological mechanisms for selectivity and persistence remain undetermined.