Lack of JC viral genomic sequences in multiple sclerosis brain tissue by polymerase chain reaction | Zendy

Buckle Guy J. | Zendy; Godec Mark S. | Zendy; Rubi Jorge U. | Zendy; Tornatore Carlo | Zendy; Major Eugene O. | Zendy; Gibbs Clarence J. | Zendy; Gajdusek D. Carleton | Zendy; Asher David M. | Zendy

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Lack of JC viral genomic sequences in multiple sclerosis brain tissue by polymerase chain reaction

Author(s) -

Buckle Guy J.,

Godec Mark S.,

Rubi Jorge U.,

Tornatore Carlo,

Major Eugene O.,

Gibbs Clarence J.,

Gajdusek D. Carleton,

Asher David M.

Publication year - 1992

Publication title -

annals of neurology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.764

H-Index - 296

eISSN - 1531-8249

pISSN - 0364-5134

DOI - 10.1002/ana.410320622

Subject(s) - progressive multifocal leukoencephalopathy , jc virus , polymerase chain reaction , slow virus , primer (cosmetics) , multiple sclerosis , pathology , nested polymerase chain reaction , leukoencephalopathy , medicine , virology , virus , biology , disease , immunology , gene , chemistry , genetics , organic chemistry

With DNA extracted from brain specimens from 19 multiple sclerosis, 5 progressive multifocal leukoencephalopathy, 1 Alzheimer's disease, and 8 nonneurological control subjects, polymerase chain reaction was performed using nested sets of primer pairs amplifying segments of the large T and VP1 antigen‐encoding sequences of JC virus. Both sequences were detected in each of the 5 brain specimens of progressive multifocal leukoencephalopathy but in none of the 19 multiple sclerosis, 1 Alzheimer's disease, or the 8 control brain specimens.

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