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Relative sparing of nitric oxide synthase–containing neurons in the hippocampal formation in Alzheimer's disease
Author(s) -
Hyman Bradley T.,
Marzloff Kristin,
Wenniger Julia J.,
Dawson Ted M.,
Bredt David S.,
Snyder Solomon H.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410320618
Subject(s) - neurotoxicity , hippocampal formation , glutamate receptor , nitric oxide synthase , neuroscience , neuronal nitric oxide synthase , endogeny , nitric oxide , alzheimer's disease , hippocampus , chemistry , disease , biology , medicine , biochemistry , endocrinology , toxicity , receptor
Nitric oxide (NO) is an endogenous neuromodulator that may mediate neurotoxic effects of glutamate. NO‐synthesizing neurons are, however, resistant to NO‐ and glutamate‐induced neurotoxicity. We now show that NO synthase neurons are selectively spared in patients with Alzheimer's disease, even in a severely affected region of the brain such as the hippocampal formation.