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Three‐ and four‐year cognitive outcome in children with noncortical brain tumors treated with whole‐brain radiotherapy
Author(s) -
Radcliffe Jerilynn,
Packer Roger J.,
Atkins Thomas E.,
Bunin Greta R.,
Schut Luis,
Goldwein Joel W.,
Sutton Leslie N.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410320411
Subject(s) - intelligence quotient , medicine , pediatrics , radiation therapy , cognition , brain tumor , brain function , el niño , chemotherapy , psychology , psychiatry , neuroscience
Cognitive function and school achievement were studied prospectively over 3 to 4 years in 19 children treated for brain tumors with whole‐brain radiotherapy; 14 of 19 also received adjuvant chemotherapy. For the group as a whole, mean IQ fell from a baseline of 104 to 92 at follow‐up( p < 0.01). Age was inversely correlated with change in IQ over time (r = 0.71; p < 0.001). Children younger than 7 years at diagnosis had a mean IQ loss 27 points, while children over 7 years at diagnosis showed no significant decrease in IQ. Decline in IQ occured between baseline and year 2 of follow‐up; none could be documented between years 2 and 4. All children younger than 7 years at diagnosis were receiveing special education at follow‐up; 50% of the children over 7 years at diagnosis were receiving supplemental educational services.