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Recurrent transverse myelitis, myasthenia gravis, and autoantibodies
Author(s) -
Lindsey J. W.,
Albers G. W.,
Steinman L.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410320319
Subject(s) - transverse myelitis , myasthenia gravis , medicine , autoantibody , anti nuclear antibody , myelitis , multiple sclerosis , autoimmune disease , pathology , immunology , antibody , spinal cord , psychiatry
A 45‐year‐old man with a longstanding diagnosis of myasthenia gravis presented with four episodes of transverse myelitis in 5 years. Each episode improved after treatment with steroids. Laboratory studies revealed no evidence of multiple sclerosis or a structural spinal lesion. He had antinuclear and anti‐DNA antibodies and the HLA‐A1, B8, DR3 haplotype known to be associated with certain autoimmune diseases. We propose an autoimmune cause for the recurrent episodes of myelitis.