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The first decade of molecular genetics in neurology: Changing clinical thought and practice
Author(s) -
Rowland Lewis P.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410320213
Subject(s) - mendelian inheritance , anticipation (artificial intelligence) , inheritance (genetic algorithm) , medical genetics , disease , neurology , genetic counseling , clinical practice , genetics , molecular genetics , biology , medicine , neuroscience , family medicine , gene , pathology , computer science , artificial intelligence
Molecular genetics has had a powerful impact on clinical neurology. Definitions of disease are changing from clinical criteria to DNA analysis, resolving questions about the nature of clinically similar but not identical diseases. Genetic counseling is more reliable. Concepts of mendelian inheritance are being tested and new forms of mutation have been discovered to explain anticipation. Nonmendelian forms of inheritance have emerged; concepts of pathogenesis are on a more secure footing; and novel treatments are being explored.