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Parkinsonism‐inducing neurotoxin MPP + : Uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA
Author(s) -
Kitayama S.,
Shimada S.,
Uhl G. R.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410320120
Subject(s) - dopamine transporter , neurotoxin , parkinsonism , dopamine , transporter , metabolite , mptp , neurotoxicity , chemistry , biology , toxicity , microbiology and biotechnology , pharmacology , biochemistry , endocrinology , medicine , gene , dopaminergic , disease , organic chemistry
Expression of a cloned dopamine transporter complementary DNA in COS cells allows these primate kidney cells to accumulate the parkinsonism‐inducing neurotoxin metabolite MPP + (1‐methyl‐4‐phenylpyridinium) avidly, and MPP + toxicity results. By documenting that the dopamine transporter can confer MPP + sensitivity to nonneural cells, these results highlight the key role that this transporter could play in mechanisms underlying parkinsonism.