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Cholinesterases in the amyloid angiopathy of Alzheimer's disease
Author(s) -
Mesulam Marsel,
Carson Keith,
Price Bruce,
Geula Changiz
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410310517
Subject(s) - cerebral amyloid angiopathy , alzheimer's disease , angiopathy , amyloid (mycology) , disease , medicine , neuroscience , degenerative disease , amyloid β , pathology , psychology , dementia , endocrinology , diabetes mellitus
Vessels affected by amyloid angiopathy in patients with Alzheimer's disease also displayed intense acetylcholinestearase and butyrylcholinesterase activity when examined by light and electron microscopy. The enzymatic properties of the vessel‐bound cholinesterases were identical to those of the cholinesterases associated with senile plaques and neurofibrillary tangles. This cholinesterase activity is of unknown origin but represents one of the very few features common to all the major pathological markers of Alzheimer's disease.