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Ascorbat neurotoxicity in cortical cell culture
Author(s) -
Hisanaga Kinya,
Sagar Stephen M.,
Sharp Frank R.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410310516
Subject(s) - neurotoxicity , neurotransmitter , extracellular , receptor , glutamate receptor , dopamine , neuron , ascorbic acid , neuroscience , programmed cell death , biology , chemistry , biochemistry , microbiology and biotechnology , medicine , endocrinology , toxicity , food science , apoptosis
Ascorbate (vitamin C)is believed to act as a neuromodulator that facilitates the release of neurotransmitters and inhibits neurotransmitter binding to receptors, including dopamine and N ‐methyl‐ D ‐aspartate receptors. Extracellular levels of ascorbate are known to reach the low millimolar range after ischemic brain injury. This study shows that treatment of cultured cortical neurons with micromolar to low millimolar ascorbate first inhibits total protein synthesis and then results in late neuronal death. Astrocytes are much less vulnerable to ascorbate than neurons. Ascorbate may exacerbate neuronal and glial damage after brain ischemia, and it may play a pathological role in other neurological diseases.