Premium
Preferential loss of striato‐external pallidal projection neurons in presymptomatic Huntington's disease
Author(s) -
Albin Roger L.,
Reiner Anton,
Anderson Keith D.,
Dure Leon S.,
Handelin Barbara,
Balfour Rosemary,
Whetsell William O.,
Penney John B.,
Young Anne B.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410310412
Subject(s) - globus pallidus , medium spiny neuron , huntington's disease , substantia nigra , neuroscience , basal ganglia , disease , degenerative disease , striatum , psychology , medicine , central nervous system disease , pathology , central nervous system , parkinson's disease , dopamine
We have reported previously that striatal projection neurons are differentially affected in the course of Huntington's disease, and in a prior patient report we noted that differential loss of striatal projection neurons occurs also in patients with presymptomatic Huntington's disease. Striatal neurons projecting to the external segment of the globus pallidus or the substantia nigra show evident loss, whereas those projecting to the internal segment of the globus pallidus appear relatively spared at presymptomatic and early stages of symptomatic Huntington's disease. We now report similar findings in a second apparently presymptomatic Huntington's disease allele carrier.