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Collagen cross‐linking of skin in patients with amyotrophic lateral sclerosis
Author(s) -
Ono Seiitsu,
Yamauchi Mitsuo
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410310313
Subject(s) - amyotrophic lateral sclerosis , medicine , physical medicine and rehabilitation , degenerative disease , dermatology , neuroscience , pathology , disease , psychology
Collagen cross‐links of skin tissue (left upper arm) from 11 patients with amyotrophic lateral sclerosis (ALS) and 9 age‐matched control subjects were quantified. It was found that patients with ALS had a significant reduction in the content of an age‐related, stable cross‐link, histidinohydroxylysinonorleucine, that was negatively correlated with the duration of illness. The contents of sodium borohydride–reducible labile cross‐links, dehydro‐hydroxylysinonorleucine and dehydro‐histidinohydroxymerodesmosine, were significantly increased and were positively associated with the duration of illness ( r = 0.703, p < 0.05 and r = 0.684, p < 0.05, respectively). The results clearly indicate that during the course of ALS, the cross‐linking pathway of skin collagen runs counter to its normal aging, resulting in a “rejuvenation” phenomenon of skin collagen. Thus, cross‐linking of skin collagen is affected in ALS.