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Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington's disease
Author(s) -
Harris Gordon J.,
Pearlson Godfrey D.,
Peyser Carol E.,
Aylward Elizabeth H.,
Roberts Joy,
Barta Patrick E.,
Chase Gary A.,
Folstein Susan E.
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410310113
Subject(s) - putamen , caudate nucleus , atrophy , magnetic resonance imaging , medicine , pathology , nuclear medicine , radiology
The characteristic pathological features of Huntington's disease (HD) are neostriatal atrophy and neuronal loss. Although neuroradiological studies often show caudate atrophy in patients with moderate HD, frequently no caudate atrophy is found early in the illness. There have been no quantitative reports to date on in vivo putamen volume measures in mild HD, although the structure is known to be neuropathologically involved in the illness. We measured volumes of caudate nucleus and putamen and bicaudate ratios (BCR) from magnetic resonance images, blind to diagnosis, in 15 patients with mild HD and 19 age‐ and sex‐matched control subjects using a computerized image analysis system. The region showing greatest atrophy was the putamen, which was reduced 50.1% in mean volume in HD patients compared with control subjects ( p <0.1). In contrast, caudate volume was reduced 27.7% ( p = 0.004). BCR was increased 28.5% in HD patients ( p = 0.0002). Discriminant function analysis was 94% effective in identifying the diagnostic group based on putamen volume alone, whereas caudate measures had considerable overlap. Correction of putamen volume for head size led to 100% separation by group. Putamen measures and BCR correlated with neurological examination scores but caudate volume did not. Volumetric measurement of putamen is a more sensitive indicator of brain abnormalities in mild HD than measures of caudate atrophy.