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Relapsing and remitting human immunodeficiency virus—associated leukoencephalomyelopathy
Author(s) -
Berger Joseph R.,
Tornatore Carlo,
Major Eugene O.,
Bruce Jocelyn,
Shapshak Paul,
Yoshioka Masaru,
Houff Sydney,
Sheremata William,
Horton Gerald F.,
Landy Howard
Publication year - 1992
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410310107
Subject(s) - astrogliosis , multiple sclerosis , medicine , immunosuppression , progressive multifocal leukoencephalopathy , brain biopsy , human immunodeficiency virus (hiv) , leukoencephalopathy , lesion , immunology , pathology , relapsing remitting , seroconversion , biopsy , central nervous system , disease
We describe a 33‐year‐old homosexual man with a steroid‐responsive, remitting and relapsing leukoencephalopathy associated with recent human immunodeficiency virus type 1 (HIV‐1) seroconversion. Biopsy of a parieto‐occipital lesion revealed demyelination and astrogliosis with focal necrosis. Detailed investigations demonstrated no pathogens in the brain other than HIV‐1. This patient illustrates that a neurological disorder clinically indistinguishable from multiple sclerosis may be the presenting manifestation of HIV‐1 infection and may occur in the absence of clinically significant immunosuppression.