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Nighttime levodopa infusions to treat motor fluctuations in advanced parkinson's disease: Preliminary observations
Author(s) -
Sage Jacob I.,
Mark Margery H.
Publication year - 1991
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410300417
Subject(s) - levodopa , parkinson's disease , medicine , physical medicine and rehabilitation , motor symptoms , disease , neuroscience , psychology
We report the clinical response of a parkinsonian patient with severe motor fluctuations who was begun on continuous, nighttime‐only levodopa infusions accompanied by oral carbidopa/levodopa use during the day. Sleep disturbances improved immediately. There was a gradual reduction in “off” time and severity of dyskinesias during the waking day. Nighttime‐only levodopa infusions have a carryover benefit to the waking hours and may be suitable for long‐term therapy to reduce daily motor fluctuations in some patients with Parkinson's disease.