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Presynaptic parkinsonism in olivopontocerebellar atrophy: Clinical, pathological, and neurochemical evidence
Author(s) -
Pascual Julio,
Pazos Angel,
del Olmo Elena,
Figols Javier,
Leno Carlos,
Berciano José
Publication year - 1991
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410300318
Subject(s) - olivopontocerebellar atrophy , parkinsonism , neurochemical , atrophy , levodopa , degenerative disease , pathological , neuroscience , pathology , psychology , dopamine receptor , progressive supranuclear palsy , dopamine , parkinson's disease , disease , medicine , central nervous system disease
The substrate for olivopontocerebellar atrophy parkinsonism is obscure due to the lack of clinical and pathological reports and the absence of studies on dopamine receptors in this entity. We describe a patient with olivopontocerebellar atrophy whose clinical presentation was levodopa‐responsive parkinsonism in whom pathological examination disclosed pronounced nigral cell loss with no striatal damage. Autoradiographic labeling with 3 H‐spiperone showed normal densities of D 2 dopamine striatal receptors. These data show that indistinguishable nigral, presynaptic parkinsonism occurs in patients with idiopathic Parkinson's disease and in patients with olivopontocerebellar atrophy, and also how a favorable response to levodopa is neither synonymous with idiopathic Parkinson's disease, nor does it exclude multiple‐system, atrophy‐related parkinsonism.