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Frequency and distribution of Alzheimer's disease in Europe: A collaborative study of 1980–1990 prevalence findings
Author(s) -
Rocca Walter A.,
Hofman Albert,
Brayne Carol,
Breteler Monique M. B.,
Clarke Michael,
Copeland John R. M.,
Dartigues JeanFrancois,
Engedal Knut,
Hagnell Olle,
Heeren Thea J.,
Jonker Cees,
Lindesay James,
Lobo Antonio,
Mann Anthony H.,
Mölsä Pekka K.,
Morgan Kevin,
O'Connor Daniel W.,
Droux Arnaldo da Silva,
Sulkava Raimo,
Kay David W. K.,
Amaducci Luigi
Publication year - 1991
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410300310
Subject(s) - dementia , disease , medicine , alzheimer's disease , demography , population , stroke (engine) , prevalence , gerontology , environmental health , mechanical engineering , sociology , engineering
We reanalyzed and compared current prevalence estimates of Alzheimer's disease in Europe. Studies characterized as follows qualified for comparison: dementia defined by the Diagnostic and Statistical Manual for Mental Disorders , 3rd edition, or equivalent criteria; Alzheimer's disease diagnosed by the National Institute of Neurological and Communicative Disorders and Stroke‐Alzheimer's Disease and Related Disorders Association or equivalent criteria; case‐finding through direct individual examination; appropriate sample size; and inclusion of institutionalized persons. Of the 23 European surveys of dementia considered, six fulfilled the inclusion criteria. When age and sex were considered, there were no major geographic differences in the prevalence of Alzheimer's disease across Europe. Overall European prevalence (per 100 population) for the age groups 30 to 59, 60 to 69, 70 to 79, and 80 to 89 years was, respectively, 0.02, 0.3, 3.2, and 10.8. Prevalence increased exponentially with advancing age and, in some populations, was consistently higher in women. Prevalence remained stable over 15 years in one study.