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The time course and magnitude of spontaneous recovery of parkinsonism produced by intracarotid administration of 1‐Methyl‐4‐Phenyl‐1,2,3,6‐tetrahydropyridine to monkeys
Author(s) -
Kurlan Roger,
Kim Michael H.,
Gash Don M.
Publication year - 1991
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410290618
Subject(s) - parkinsonism , spontaneous recovery , anesthesia , medicine , rating scale , levodopa , psychology , parkinson's disease , developmental psychology , disease
We studied rhesus monkeys with hemiparkinsonism or bilateral parkinsonism produced by unilateral or bilateral intracarotid administration of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine. Using a standardized clinical rating scale, 4 hemiparkinsonian monkeys showed a 13 to 56% (mean, 36%) spontaneous improvement during an obsevation period of up to 25 weeks. Generally, recovery leveled off after 14 weeks. Four bilaterally parkinsonian monkeys showed a 5 to 42%(mean, 22percnt;) improvement over a period of up to 30 weeks. Our findings emphasize that spontaneous recovery is a potentially confounding characteristic of this monkey model when used for assessing novel antiparkinsonian therapies.