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Regional variation in brain lactate in leigh syndrome by localized 1 H magnetic resonance spectroscopy
Author(s) -
Detre John A.,
Wang Zhiyue,
Bogdan Andrew R.,
Gusnard Debra A.,
Bay Carolyn A.,
Bingham Peter M.,
Zimmerman Robert A.
Publication year - 1991
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410290219
Subject(s) - leigh disease , brainstem , functional magnetic resonance spectroscopy of the brain , basal ganglia , magnetic resonance imaging , nuclear magnetic resonance , nuclear magnetic resonance spectroscopy , cortex (anatomy) , medicine , pathology , chemistry , neuroscience , central nervous system , biology , physics , radiology , biochemistry , mutation , gene
Localized water‐suppressed 1 H magnetic resonance spectroscopy was performed in an 11‐month‐old infant with Leigh syndrome. Spectra obtained from the basal ganglia, occipital cortex, and brainstem showed elevations in lactate, which were most pronounced in regions where abnormalitites were seen with routine T2‐weighted magnetic resonance imaging. This approach has allowed us to examine metabolism in brain tissue directly and noninvasively, and may provide a sensitive means for evaluating metabolic disease and the response to therapy in the brain.