Premium
Apparent response of subacute sclerosing panencephalitis to intrathecal interferon alpha
Author(s) -
Miyazaki Masahito,
Hashimoto Toshiaki,
Fujino Kayo,
Goda Tomoko,
Tayama Masanobu,
Kuroda Yasuhiro
Publication year - 1991
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410290118
Subject(s) - subacute sclerosing panencephalitis , intrathecal , medicine , alpha interferon , alpha (finance) , interferon , immunology , pathology , gastroenterology , anesthesia , surgery , measles , measles virus , vaccination , construct validity , patient satisfaction
An 8‐years‐old boy with subacute sclerosing panencephalitis (SSPE) was treated with 1.0 to 3.0 × 10 6 IU human interferon alpha (IFN) by the intrathecal route weekly or fortnightly. Pronounced improvement of clinical and electroencephalographic findings were observed in a dose‐dependent manner. Our patient raises hope that IFN can induce sustained remission in patients with SSPE.