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Neuroanatomy of fragile X syndrome: The posterior fossa
Author(s) -
Reiss Allan L.,
Aylward Elizabeth,
Freund Lisa S.,
Joshi Paramjit K.,
Bryan R. Nick
Publication year - 1991
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410290107
Subject(s) - cerebellar vermis , hypoplasia , fragile x syndrome , anatomy , fourth ventricle , atrophy , neuroanatomy , magnetic resonance imaging , posterior fossa , posterior cranial fossa , medicine , fossa , cerebellum , cerebellar hypoplasia (non human) , pathology , radiology , psychiatry
Abstract The occurrence and specificity of posterior fossa abnormalities as measured from magnetic resonance images of the brain were investigated in a group of 14 males with fragile X syndrome and comparison groups consisting of 17 males with other causes of developmental disability and 18 males with normal IQs. The size of the posterior cerebellar vermis was significantly decreased and the fourth ventricle significantly increased in the group of males with fragile X syndrome compared with males in both comparison groups. These neuroanatomical abnormalities appeared to be secondary to hypoplasia rather than atrophy.