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Stiff‐man syndrome: A GABAergic autoimmune disorder with autoantigenic heterogeneity
Author(s) -
Gorin Dr F.,
Baldwin B.,
Tait R.,
Pathak R.,
Seyal M.,
Mugnaini E.
Publication year - 1990
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410280518
Subject(s) - glutamate decarboxylase , autoantibody , gabaergic , stiff person syndrome , cerebrospinal fluid , endocrinology , medicine , chemistry , antibody , enzyme , immunology , biochemistry , receptor
Autoantibodies that reacted with cell bodies and axon terminals of gamma‐aminobutyric acid (GABA)ergic neurons were present in the serum and cerebrospinal fluid in a patient with stiff‐man syndrome with type I diabetes. Immunoblot experiments using this patient's serum and cerebrospinal fluid did not corroborate an earlier observation that these autoantibodies are directed against the GABAergic cytosolic enzyme, L‐glutamic acid decarboxylase. While L‐glutamic acid decarboxylase autoantibodies may be associated with this syndrome, they do not appear to be easily demonstrated.