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Human immuno deficiency virus (HIV)–associated myopathy: Immunocytochemical identification of an HIV antigen (gp 41) in muscle macrophages
Author(s) -
Chad David A.,
Smith Thomas W.,
Blumenfeld Andrew,
Fairchild Patrick G.,
Degirolami Umberto
Publication year - 1990
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410280418
Subject(s) - endomysium , pathology , myopathy , pathogenesis , immunostaining , immunopathology , muscle biopsy , immunology , macrophage , antigen , inflammation , medicine , biology , biopsy , virology , immunohistochemistry , disease , coeliac disease , in vitro , biochemistry
In a patient with acquired immunodeficiency disease syndrome (AIDS) and muscle biopsy specimen disclosed degeneration of muscle fibers, regeneration, and focal endomysial mononuclear inflammation. A conspicuous feature was the presence of perivascular macrophages within the endomysium that showed positive immunostaining for human immunodeficiency virus (HIV) (gp 41) antigen. HIV was not detected within myofibers. Our findings suggest an important role for the HIV‐infected macrophage in the pathogenesis of this myopathy.