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Motor neuron disease in a patient with a monoclonal IgMk directed against GM1, GD1b, and high‐molecular‐weight neural‐specific glycoproteins
Author(s) -
NobileOrazio E.,
Legname G.,
Daverio R.,
Carpo M.,
Giuliani A.,
Sonnino S.,
Scarlato G.
Publication year - 1990
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410280215
Subject(s) - glycoprotein , lower motor neuron , glycolipid , monoclonal antibody , epitope , peanut agglutinin , lectin , motor neuron , polyneuropathy , upper motor neuron , spinal cord , chemistry , medicine , disease , neuroscience , biochemistry , amyotrophic lateral sclerosis , biology , immunology , antibody
In a patient with motor neuron disease and benign IgMk monoclonal gammopathy, the M rprotein reacted with the glycolipids GM1, GD1b, and asialo GM1 and, by immunoblot, with some high‐molecular‐weight neural‐specific glycoproteins. The main reactive bands had an approximate molecular weight of 250 and 400 kd, were most concentrated in the spinal cord, and were also bound by the lectin peanut agglutinin. The presence of the Gal(b̃1‐3) GalNAc epitope on these neural‐specific glycoproteins may help to explain the selective neurological impairment of the patient.