Premium
Ubiquitin immunoreactivity in kuru plaques in Creutzfeldt‐Jakob disease
Author(s) -
Suenaga Toshihiko,
Hirano Asao,
Llena Josefina F.,
KsiezakReding Hanna,
Yen ShuHui,
Dickson Dennis W.
Publication year - 1990
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410280210
Subject(s) - kuru , pathology , medicine , disease , creutzfeldt jakob syndrome , ubiquitin , virology , biology , prion protein , scrapie , biochemistry , gene
Cerebellar kuru plaques in 2 cases of Creutzfeldt‐Jakob disease were studied immunohistochemically. Similar to cerebellar senile plaques in Alzheimer's disease, many kuru plaques contained ubiquitin‐positive, tau‐negative small granular elements, presumably representing dystrophic neurites. Our results suggest that similar mechanisms are involved in neuritic changes in cerebellar plaques in Creutzfeldt‐Jakob and Alzheimer's diseases despite differences of amyloid proteins in the plaques.