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Localization of epileptic foci using a large‐area magnetometer and functional brain anatomy
Author(s) -
Tiihonen J.,
Hari Dr R.,
Kajola M.,
Nousiainen U.,
Vapalahti M.
Publication year - 1990
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410270310
Subject(s) - gradiometer , temporal lobe , magnetometer , squid , neuroscience , epilepsy , magnetoencephalography , anatomy , skull , physics , electroencephalography , nuclear magnetic resonance , medicine , psychology , biology , magnetic field , ecology , quantum mechanics
We used a large‐area, 7‐channel, first‐order superconducting quantum interference device (SQUID) gradiometer to preoperatively determine the sites of epileptic foci in 2 patients with intractable temporal lobe seizures. The equivalent dipoles for the epileptic spikes were located with respect to external landmarks of the skull and in relation to the generation sites of magnetic auditory evoked responses. It was also possible, for the first time, to determine the location of the equivalent source using simultaneously measured data from seven locations only. The sites of the equivalent dipoles, in the right temporal lobe, agreed with the electrocorticographic and depth electrode recordings made during the operation.