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Isoelectric focusing studies of serum and cerebrospinal fluid in patients with antecedent poliomyelitis
Author(s) -
SalazarGrueso Edgar F.,
Grimaldi Luigi M. E.,
Roos Raymond P.,
Variakojis Renata,
Jubelt Burk,
Cashman Neil R.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260604
Subject(s) - cerebrospinal fluid , medicine , poliomyelitis , immunology , immune system , multiple sclerosis , central nervous system , pathology
The post‐poliomyelitis syndrome (PPS) refers to symptoms of new weakness, fatigue, and pain years after recovery from acute poliomyelitis. Oligoclonal IgG bands have been reported in the cerebrospinal fluid (CSF) from PPS patients, suggesting that the syndrome is immune mediated or caused by persistent viral infection. We studied 15 paired serum and CSF samples and 6 unpaired CSF samples from a total of 21 patients with a prior history of poliomyelitis. Quantitative immune studies failed to show evidence for increased intrathecal IgG production relative to patients with noninflammatory central nervous system (CNS) disease. We found definite oligoclonal IgG bands in the CSF from only 1 patient, who also carried a diagnosis of multiple sclerosis. An isoelectric focusing poliovirus antigen overlay study showed evidence that suggested a CNS‐specific antipoliovirus immune response in only 1 patient. Our results fail to support a dysimmune or persistent viral cause for post‐poliomyelitis progressive muscular atrophy or PPS.