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Deprenyl suppresses the oxidant stress associated with increased dopamine turnover
Author(s) -
Cohen Gerald,
Spina Mary Beth
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260518
Subject(s) - dopamine , glutathione , glutathione disulfide , striatum , chemistry , endocrinology , medicine , haloperidol , oxidative stress , enzyme , biochemistry
Tissue glutathione disulfide (GSSG) was studied as an index of changes in redox state in the striatum. When increased turnover of dopamine was provoked in mice by injection of haloperidol (1 mg/kg), the concentration of GSSG in the striatum tripled. Deprenyl (2.5 mg/kg) suppressed the rise in GSSG by 71.9%. These results indicate that deprenyl suppresses an oxidant stress associated with increased dopamine turnover.