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A case of adult‐onset dementia with argyrophilic grains
Author(s) -
Itagaki S.,
McGeer P. L.,
Akiyama H.,
Beattie B. L.,
Walker D. G.,
Moore G. R. W.,
McGeer E. G.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260517
Subject(s) - tangle , pathology , choline acetyltransferase , dementia , acetylcholinesterase , cerebral cortex , neurofibrillary tangle , pathological , alzheimer's disease , medicine , biology , disease , central nervous system , senile plaques , biochemistry , enzyme , mathematics , pure mathematics
A case of progressive dementia in a 68‐year‐old woman was characterized by the postmortem finding of widespread argyrophilic grains in the cerebral cortex. The grains consisted of 10‐ to 13‐nm filaments in deposits ranging up to 9 μm in length and 3 μm in diameter. The grains stained positive with Alz‐50 monoclonal antibody. Cortical brain tissue levels were minimally elevated for acetylcholinesterase, moderately reduced for choline acetyltransferase, and sharply reduced for glutaminase. Although the case was clinically indistinguishable from Alzheimer's disease, plaque and tangle pathological findings were absent. We confirm cortical changes of the type described by Braak and Braak and provide additional data on subcortical changes in this case.