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Neuropathological changes in early HIV‐1 dementia
Author(s) -
McArthur Justin C.,
Becker P. Scott,
Parisi Joseph E.,
Trapp Bruce,
Selnes Ola A.,
Cornblath David R.,
Balakrishnan Janaki,
Griffin John W.,
Price Donald
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260516
Subject(s) - astrocytosis , pallor , dementia , medicine , atrophy , multicenter aids cohort study , pathology , neuropathology , pathological , white matter , human immunodeficiency virus (hiv) , pediatrics , immunology , viral disease , sida , disease , magnetic resonance imaging , radiology , immunohistochemistry
Early pathological abnormalities in human immunodeficiency virus (HIV‐1)–related dementia have not been well documented. We report a homosexual man with fatigue and intermittent diarrhea in whom early HIV‐1–related dementia was demonstrated during neurological screening in the Multicenter AIDS Cohort Study. Within 4 months he died of massive epistaxis, and the brain revealed astrocytosis of white matter and mild pallor of myelin staining in the absence of inflammation, multinucleated giant cells, and brain atrophy.