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Galactosylceramide: A reliable serum index of demyelination in multiple sclerosis
Author(s) -
Lubetzki C.,
PharmD Y. Thuillier,
PharmD A. Galli,
LyonCaen O.,
Lhermitte F.,
Zalc B.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260319
Subject(s) - multiple sclerosis , myelin , medicine , myelin sheath , disease , demyelinating disease , gastroenterology , pathology , immunology , central nervous system
Eight patients with multiple sclerosis were followed for several months to determine if serum levels of galactosylceramide, a major lipid component of myelin, correlate with the clinical evolution of the disease. In the patients with the chronic progressive form of multiple sclerosis, galactosycleramide remained undetectable. In the patients with relapsing‐remitting multiple sclerosis, there was a good correlation between the elevation of serum galactosylcermide levels and clinical relapses. This serum assay should prove of value in the follow‐up of patients with multiple sclerosis.