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Activated T cells in HTLV‐I–associated myelopathy: Autologous mixed lymphocyte reaction
Author(s) -
Minato Seiichiro,
Itoyama Yasuto,
Fujii Naoki,
Kira Junichi,
Goto Ikuo,
Yamamoto Naoki
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260316
Subject(s) - myelopathy , mixed lymphocyte reaction , lymphocyte , medicine , immunology , t lymphocyte , peripheral blood , cell , t cell , biology , spinal cord , immune system , psychiatry , genetics
We examined the autologous mixed lymphocyte reaction in human T‐cell lymphotropic virus type I‐associated myelopathy to elucidate the known increase in spontaneous proliferation of peripheral blood lymphocytes. Proliferative responses in the autologous mixed lymphocyte reaction test were significantly increase (34,205 cpm) in cells from 9 patients with the myelopathy, as compared with findings (18,695 cpm) in the control subjects. When non‐T‐cell fractions were depleted from autologous mixed lymphocyte reaction cultures, proliferative responses were completely suppressed in the control subjects, while proliferation of the peripheral blood lymphocytes from the groups with the myelopathy were not affected by depletion of non‐T‐cell fractions. The increase in spontaneous proliferation of peripheral blood lymphocytes from the groups with the myelopathy were not affected by depletion of non‐T‐cell fractions. The increase in spontaneous proliferation of peripheral blood lymphocytes in patients with the myelopathy is probably not related to an increase in autologous mixed lymphocyte reactions.