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Cardiogenic brain embolism and lupus anticoagulant
Author(s) -
Young Seymour M.,
Fisher Marc,
Sigsbee Ann,
Errichetti Annmarie
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260313
Subject(s) - lupus anticoagulant , medicine , cerebral embolism , thrombosis , anticoagulant , systemic lupus erythematosus , ischemia , cardiology , embolism , etiology , disease
The lupus anticoagulant, an acquired immunoglobulin associated with an increased tendency for thrombosis, has been linked to the occrence of cerebral ischemia presumably related to in situ thrombosis. Cardioembolic cerebral ischemic events have rarely been reported. We encountered 2 patients with focal cerebral ischemia, substantial mitral valvular masses, and a circulating lupus anticoagulant. In each, diagnostic evaluation supported a cardioembolic etiology. These findings illustrate the need for evaluating patients with cerebral ischemic events for a cardioembolic source when a circulating lupus anticoagulant is present.