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Alterations of hippocampal acetylcholinesterase in human temporal lobe epilepsy
Author(s) -
Green Robert C.,
Blume Howard W.,
Kupferschmid Seth B.,
Mesulam MMarsel
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260307
Subject(s) - hippocampal sclerosis , temporal lobe , hippocampal formation , epilepsy , dentate gyrus , acetylcholinesterase , hippocampus , neuroscience , pathology , anatomy , biology , medicine , biochemistry , enzyme
Hippocampal sclerosis is the most common pathological finding associated with human temporal lobe epilepsy. Histochemical study with acetylcholinesterase (AChE) staining was used to investigate 7 surgically resected temporal lobes with hippocampal sclerosis from patients with temporal lobe epilepsy. In all 7 specimens, an abnormal but consistent pattern of staining was noted. In the hilum of the dentate gyrus, AChE‐rich polymorphic cells were relatively preserved in comparison to the pyramidal neurons. In Ammon's horn, AChE fibers were lost in regions corresponding to the pyramidal cell dropout. AChE fibers wre also lost along the inner portion of the molecular layer of the dentate gyrus, yet they were preserved within the outer portions of the molecular layer. These findings provide additional evidence for the relative selectivity of hippocampal pathology in human temporal lobe epilepsy.