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Acetaminophen metabolism by cytochrome P450 monooxygenases in Parkinson's disease
Author(s) -
Factor Stewart A.,
Weiner William J.,
Hefti Franz
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260219
Subject(s) - acetaminophen , urine , carbidopa , monooxygenase , parkinson's disease , levodopa , metabolism , cytochrome p450 , medicine , cyp2d6 , antipyretic , endocrinology , gastroenterology , disease , pharmacology , analgesic
It has been suggested that alterations in the activity of cytochrome P450 monooxygenases may play a role in the pathogenesis of Parkinson's disease, particularly in patients who had onset before the age of 40. We studied the P450‐mediated metabolism of acetaminophen to 3‐hydroxy‐acetaminophen in 26 patients with Parkinson's disease and in 18 control subjects. After subjects ingested 1,000 mg acetaminophen, urine was collected under controlled conditions. Acetaminophen and 3‐hydroxy‐acetaminophen were measured in the urine using newly developed high‐pressure liquid chromatography methods. The ratio of 3‐hydroxy‐acetaminophen to acetaminophen was calculated for each patient and no significant differences were observed in patients compared with control subjects. Abnormal metabolism was not observed in patients who had onset of Parkinson's diseae at or before the age of 40. In addition, no difference in metabolic activity was observed between the patients who were treated with levodopa/carbidopa and those who were not treated. These findings suggest that there are no alterations of P450‐mediated metabolism of acetaminophen in patients with Parkinson's disease.