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Isolation of herpes simplex virus type 1 during first attack of multiple sclerosis
Author(s) -
BergstOum Tomas,
Andersen Oluf,
Vahlne Anders
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260218
Subject(s) - multiple sclerosis , herpes simplex virus , virology , isolation (microbiology) , virus isolation , medicine , simplex , virus , biology , immunology , mathematics , microbiology and biotechnology , combinatorics
Abstract Herpes simplex virus type 1 was isolated from the cerebrospinal fluid of a patient during the first attack of multiple sclerosis. This is the first virus to be isolated from the central nervous system of a living patient with MS. The virus was identified as herpes simplex virus type 1 by restriction endonuclease analysis and by an enzytme immunoassay using monoclonal antibodies. Antibodies against type 1 but not type 2 were detected in consecutive samples of serum and cerebrospinal fluid. The patient has since entered a progressive phase of multiple sclerosis. The isolated type 1 strain might be of pathogenetic relevance to the development of multiple sclerosis in this patient.