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Direct evidence for calcium‐induced ischemic and reperfusion injury
Author(s) -
Uematsu Daisuke,
Greenberg Joel H.,
Reivich Martin,
Hickey William F.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260217
Subject(s) - calcium , medicine , cardiology , ischemia
Changes in cytosolic free calcium ([Ca 2+ ] i ) in the cat cortex were measured in vivo by indo‐1 fluorometry during cerebral ischemia and reperfusion and were correlated to the histopathological ischemic changes. These changes were most pronounced in stroke cases with an increase in [Ca 2+ ] i throughout the ischemic and reperfusion periods. Cases without a [Ca 2+ ] i increase showed no histopathological change in the cortical gyrus in which [Ca 2+ ] i was measured. The data support the hypothesis that an increase in [Ca 2+ ] i during cerebral ischemia and reperfusion leads to neuronal damage.