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Altered glucose metabolism in microvessels from patients with Alzheimer's disease
Author(s) -
Marcus David L.,
de Leon Mony J.,
Goldman Jeffrey,
Logan Jean,
Christman David R.,
Wolf Alfred P.,
Fowler Joanna S.,
Hunter Kevin,
Tsai Jir,
Pearson John,
Freedman Michael L.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260114
Subject(s) - hexokinase , positron emission tomography , alzheimer's disease , carbohydrate metabolism , metabolism , medicine , endocrinology , disease , energy metabolism , cortex (anatomy) , degenerative disease , chemistry , biology , glycolysis , neuroscience , nuclear medicine
Microvessels isolated from temporal of cortex of patients with Alzheimer's disease showed decreased uptake of glucose when compared with vessels from age‐matched or young control subjects. This was due to decreased hexokinase activity in the Alzheimer samples, as determined by ion exchange chromatography. This finding was confirmed independently by determination of the phosphorylation constant for hexokinase, K 3 , using positron emission tomography. The results suggest that Alzheimer's disease may result from a global defect in brain energy metabolism.