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The pedunculopontine nucleus in Parkinson's disease
Author(s) -
Zweig R. M.,
Jankel W. R.,
Hedreen J. C.,
Mayeux R.,
Price D. L.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410260106
Subject(s) - pedunculopontine nucleus , parkinson's disease , neuroscience , pedunculopontine tegmental nucleus , disease , nucleus , medicine , deep brain stimulation , psychology
This study demonstrated a significant loss of neurons within the lateral part of the pedunculoponite nucleus pars compacta in individuals with idiopathic Parkinson's disease and in individuals with combined Parkinson's and Alzheimer's disease. We also examined the extent of neuronal loss within the substantia nigra pars compacta, locus ceruleus, dorsal raphe nucleus, and nucleus basalis of Meynert. The number of pedunculopontine nucleus pars compacta neurons in the patients with Parkinson's or Parkinson's and Alzheimer's disease was reduced (average, 40°) in comparison with the number in control subjects or patients with Alzheimer's disease ( p < 0.01). This finding correlated significantly with the extent of loss of substantia nigra pars compacta neurons ( p < 0.01).