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Cerebrospinal fluid transthyretin in the neonate and blood–cerebrospinal fluid barrier permeability
Author(s) -
Larsen Paul D.,
Delallo Leonard
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410250617
Subject(s) - transthyretin , cerebrospinal fluid , csf albumin , blood–brain barrier , meningitis , medicine , central nervous system , pediatrics
Abstract We measured transthyretin levels in the cerebrospinal fluid (CSF) of newborn infants, older children, patients with viral and bacterial meningitis, and adults with increased CSF protein levels. Neonatal CSF transthyretin levels are elevated disproportionately in comparison to levels in the other groups. We conclude that increased levels of transthyretin in the CSF of neonates are not explained by increased permeability of the blood–CSF barrier.