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Postmortem analysis of adrenal–medulla–to–caudate autograft in a patient with parkinson's disease
Author(s) -
Hurtig Howard,
Joyce Jeffrey,
Sladek John R.,
Trojanowski John Q.
Publication year - 1989
Publication title -
annals of neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.764
H-Index - 296
eISSN - 1531-8249
pISSN - 0364-5134
DOI - 10.1002/ana.410250613
Subject(s) - adrenal medulla , tyrosine hydroxylase , dopamine , striatum , caudate nucleus , parkinsonism , medicine , transplantation , dopamine receptor , parkinson's disease , endocrinology , neurofilament , pathology , disease , catecholamine , immunohistochemistry
A 53‐year‐old physician who had a 10‐year history of progressive idiopathic parkinsonism survived for 4 months after autologous adrenal‐medulla‐to‐right‐caudate autograft but he received little clinical benefit. A small number of chromaffin cells in the graft site survived; they expressed neurofilament proteins and chromogranin A, but scant tyrosine hydroxylase. The striatum on both sides showed almost complete loss of [ 3 H]mazindol binding to dopamine‐uptake sites; the density of dopamine receptors was decreased adjacent to the transplant but increased rostral to the transplant. These results demonstrate that autografted chromaffin cells can survive for 4 months after transplantation and that related changes in dopamine receptors can be quantified.